PALMITOYLETHANOLAMIDE NO FURTHER A MYSTERY

Of Notice is that, due to PEA’s significant lipophilicity, micronized or ultra-micronized formulations are considered to generally be a lot more easily absorbable, with extra favorable pharmacokinetics and better efficacy. Though There exists some evidence supporting this concept, there remains to be no evidence from the superiority of micronized

2015). These reports, taken together, recommend that, Though a immediate activation of GPR55 or PPAR‐α takes place, PEA can create its anti‐inflammatory motion during the intestine also via oblique activation of CB1 and CB2 receptors, possibly on account of the ability of this compound to potentiate the action of endocannabinoids at these rece